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I'm interested in modelling active matter using multi scale approaches. My PhD work is oriented on microscale mechanisms of muscle contraction and I am now working on a multiscale model of the heart.
Microscale mechanical model of muscle elementary contractile units
My PhD thesis focuses on muscle contraction and propose a mechanical model of the power-stroke phenomenon occurring in elementary contractile units called sarcomeres, at the microscale of muscle tissue.
My study of this mechanism revealed collective effects inside muscle fibers. Such collective effects arising even in the absence of metabolic fuel, are the consequence of long range interactions between molecular motors at the microscale. The proposed model explains some counter-intuitive experimental observations and suggests a design of muscle-like metamaterials.
I also worked on coarse graining procedures for stochastic system with long range interactions.
Keywords: Statistical physics/mechanics, phase transitions, molecular motors, long range interactions
Multiscale modelling of the heart
I am currently working on a multiscale model of heart tissue. We developed reduced formulation of a 3D model of the whole heart for validation and calibration purposes. The reduced formulations are a useful tool to test and validate modelling assumption and pre-calibrate CPU-time consuming 3D simulations. Such reduced models can be used for real time simulations with direct clinical applications.
Keywords: Model reduction,
- 2008-2011 -- PhD Thesis: Fast Force Recovery in skeletal muscle.
Dir: Lev Truskinovsky and Jean-Marc Allain
- 2007-2008 -- Engineer for the Centre Scientifique et Technique du Bâtiment
Energy performance of buildings
- 2006-2007 -- MSc. in Material for Structure and Energy at Ecole Polytechnique
Thesis on Tape casting of proton conducting ceramic membranes for fluel cell applications
- 2003-2006 -- Eng. degree, Nationale des Ponts et Chaussées