Matthieu Caruel

M3disim - 15Post-Doctoral Researcher

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Research

I'm interested in modelling active matter using multi scale approaches. My PhD work is oriented on microscale mechanisms of muscle contraction and I am now working on a multiscale model of the heart.

Microscale mechanical model of muscle elementary contractile units

My PhD thesis focuses on muscle contraction and propose a mechanical model of the power-stroke phenomenon occurring in elementary contractile units called sarcomeres, at the microscale of muscle tissue.

My study of this mechanism revealed collective effects inside muscle fibers. Such collective effects arising even in the absence of metabolic fuel, are the consequence of long range interactions between molecular motors at the microscale. The proposed model explains some counter-intuitive experimental observations and suggests a design of muscle-like metamaterials.

I also worked on coarse graining procedures for stochastic system with long range interactions.

Keywords: Statistical physics/mechanics, phase transitions, molecular motors, long range interactions

Collaborators: Lev Truskinovsky, Jean-Marc Allain, Vincenzo Lombardi, Tony Lelièvre and Pierre Recho.

Multiscale modelling of the heart

I am currently working on a multiscale model of heart tissue. We developed reduced formulation of a 3D model of the whole heart for validation and calibration purposes. The reduced formulations are a useful tool to test and validate modelling assumption and pre-calibrate CPU-time consuming 3D simulations. Such reduced models can be used for real time simulations with direct clinical applications.

Keywords: Model reduction,

Collaborators: Dominique Chapelle, Philippe Moireau, Radomir Chabiniok (King's College London), Yves Lecarpentier (Pitié-Salpétrière hospital, Paris)

Publications

They talk about our work on the web, click here and in Nature Physics ; view article or go to Nature Physics webpage

Background

  • 2008-2011 -- PhD Thesis: Fast Force Recovery in skeletal muscle.
    Dir: Lev Truskinovsky and Jean-Marc Allain
  • 2007-2008 -- Engineer for the Centre Scientifique et Technique du Bâtiment
    Energy performance of buildings
  • 2006-2007 -- MSc. in Material for Structure and Energy at Ecole Polytechnique
    Thesis on Tape casting of proton conducting ceramic membranes for fluel cell applications
  • 2003-2006 -- Eng. degree, Nationale des Ponts et Chaussées
    Mechanical Engineering