TOFMOD: Predictive modeling for tetralogy of Fallot patients
- TOFMOD is an Inria Associated Team funded by Inria France and Pediatric Cardiac MR Imaging Lab of UT Southwestern Medical Center Dallas (UTSW) and formed by researchers from the M3DISIM team (Inria Saclay), UTSW Medical Center Dallas and additional participants from MRI and cardiology departments (London, Prague).
- The aim of TOFMOD team is to address various issues in patients with repaired Tetralogy of Fallot (rTOF) by including biomechanical modeling, i.e. adding physics and physiology into the loop of clinical exams and management.
- In the patients with rTOF we identified problems of optimal timing of intervention as e.g. a pulmonary valve replacement therapy (PVR) or branch pulmonary artery (PA) stenting. In addition, we would like to increase understanding of failing of LV in what-is-classicaly-known to be an "RV disease", as rToF patients are known to develop LV failure earlier than the general population.
- While tackling the cohort of rTOF patients - i.e. a typical disease of right ventricle (RV), RV outflow tract (RVOT) including pulmonary valve, and branch pulmonary arteries (PA's) - the methods are in essence more universal and we are in fact exploring their applicability between LV & RV, pulmonary & aortic valve, and pulmonary artery & aorta.
- These leads to three main objectives of ToFMOD:
- Ventricular mechanics and its biomechanical modeling: aiming to optimize the timing of PVR
- Ventricular motion characterization augmented by modeling
- Characterizing the flow through pathological valve by using fluid mechanics aiming to optimize the timing of branch-PA stenting
- PVR is the therapy of choice in volume-overloaded RV due to insufficient pulmonary valve. The dilated RV may even shrink back to normal size, if the PVR is performed "not too late". The lifespan of the replaced pulmonary valve is typically 5-10 years, i.e. the rToF patients need several re-interventions during their life. Therefore, the PVR procedure tends to be postponed to "as late as possible", however prior to an irreversibility of the RV dilatation or other adverse effects occur.
- Branch PA stenosis is typically managed by stenting. The timing of re-stenting is however not clear, and assessing the already stented artery by magnetic resonance imaging may be challenging due to artifacts caused by the stent. Couplling of image data with a model has the potential to augment the information from clinical exam.
- A book chapter named "Translational Cardiovascular Modeling, Tetralogy of Fallot and Modeling of Diseases" (preprint on HAL) demonstrates a number of problems associated to TOFMOD. The chapter will appear in the book Modeling Biomaterials (Birkhauser, eds. Josef Malek and Endre Suli).
Members of the TOFMOD Associated Team
- UTSW: G. Greil, T. Hussain (PI), A. Tandon
- Inria: R. Chabiniok (PI), D. Chapelle, M. Genet, M. Gusseva, P. Moireau
- Other participants: K. Pushparajah, B. Ruijsink (BMEIS King's College London); K. Skardova (Solovska), J. Kovar, R. Fucik, T. Oberhuber (Czech Technical University in Prague & IKEM Prague); J. Tintera, R. Galabov (IKEM Prague)
Events
- Journal paper: "Time-synchronization of invasive cardiac magnetic resonance data using a biomechanical model for pressure-volume loop analysis" (peer-reviewed letter to editor) was published publication in Journal of Magnetic Resonance Imaging (JMRI), see HAL link. This is a collaborative work of UTSW, Inria and UT Austin (TOFMOD objectives #1).
- TOFMOD in International Society for Magnetic Resonance in Medicine (ISMRM 2022): K. Skardova, K. Frickova, T. Pevny, J. Tintera, T. Oberhuber, and R. Chabiniok: “Combining machine learning and mathematical modeling in estimation of T1 relaxation time”. In: Proceedings of Annual Meeting of International Society for Magnetic Resonance Imaging in Medicine (ISMRM).
- Journal paper: "Three-dimensional flows of incompressible Navier-Stokes fluids in tubes containing a sinus, with varying slip conditions at the wall" (supported by TOFMOD) was published in Applications in Engineering Science. The work is part of TOFMOD objectives #3.
- March 24, 2022: PhD defense of M. Gusseva on "Cardiac Biomechanical Modeling for Chronic Ventricular Loading" supervised by D. Chapelle (Inria), T. Hussain (UTSW) and R. Chabiniok (Inria & UTSW)
- Journal paper "Prediction of ventricular mechanics after pulmonary valve replacement in tetralogy of Fallot by biomechanical modeling: A step towards precision healthcare" was published in Annals of Biomedical Engineering (HAL link). This is a collaborative work of UTSW, Inria and UT Austin (TOFMOD objectives #1).
- Journal paper on "Altered aortic hemodynamics and relative pressure in patients with dilated cardiomyopathy" was published in Journal of Cardiovascular Translational Research by the group of David Nordsletten (King's College London and University of Michigan), with a contribution of TOFMOD (within TOFMOD objectives #3, large vessel flow).
- Journal paper "Biomechanical Modeling to Inform Pulmonary Valve Replacement in Tetralogy of Fallot Patients after Complete Repair" was published in Canadian Journal of Cardiology (HAL link). This is a collaborative work of UTSW, Inria and UT Austin (TOFMOD objectives #1).
- Journal paper "Right-Left Ventricular Shape Variations in Tetralogy of Fallot: Associations with Pulmonary Regurgitation" was published in Journal of Cardiovascular Magnetic Resonance. This is work by the group of Alistair Young (King's College London and University of Auckland) with various collaborations (contribution of TOFMOD, within TOFMOD objectives #1).
- June 24, 2021: Invited talk at Workshop on Congenital Heart Diseases (within Functional Imaging and Modeling of Heart conference FIMH2021, Stanford, USA, online),
- June 21, 2021: Special theme session on Multisystem Inflammatory Syndrome in Children (MIS-C, PIMS-TS) is organized during Functional Imaging and Modeling of Heart Conference FIMH2021
- Journal paper "Left ventricular torsion obtained using equilibrated warping in patients with repaired Tetralogy of Fallot" was published in Pediatric Cardiology, see PubMed and HAL links. This is a collaborative work of UTSW, Inria, Czech Technical University and Boston Children's hospital (TOFMOD objectives #2).
- February 24, 2021: R. Chabiniok presented "Translational Cardiovascular Modeling -- Tetralogy of Fallot & Modeling of Diseases TOFMOD" at Virtual Physiological Human institute (VPHi) Keynote webinar series, recorded version accessible also on this Youtube link.
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Journal paper "A benchmark problem to evaluate implementational issues for three-dimensional flows of incompressible fluids subject to slip boundary conditions" was published in Applications in Engineering Science. This collective work with Mathematical Institute of Charles University in Prague, Texas A&M and UT Houston is a part of TOFMOD objectives #3 (large vessel flow).
- Journal paper on "A Harmonic Phase Interpolation Method for the Estimation of Motion from Tagged MR Images (HARP-I)" was published in IEEE TMI by the group of Sergio Uribe in Santiago de Chile (with a contribution of TOFMOD, within TOFMOD objectives #2).
- August 25, 2020: TOFMOD 2020 workshop, as a satellite event of the VPH2020 conference, will take place in Paris.
- Journal paper on "Model-augmented monitoring of cardiovascular physiology during general anesthesia" was published in PLOS ONE (a part of TOFMOD objectives #1 and details are available in M3DISIM news).
- Journal paper on "Non-rigid registration of image series to map myocardial fibrosis", in the scope of TOFMOD associated team was published in Series S of Discrete and Continuous Dynamical Systems (preprint available via HAL). The work is a part of TOFMOD objectives #2 (model-constrained image processing). The details are available on M3DISIM news.
- Journal paper on coupling between modeling of large vessel flow and magnetic resonance imaging was published in Magnetic Resonance Materials in Physics, Biology and Medicine. The work is part of TOFMOD objectives #3 and details are available in M3DISIM news.
- Journal paper on Fontan circulation modeling was published in PLOS ONE. The work is part of ToFMOD objectives #1 and details are available in M3DISIM news.
- Co-organization of Doctoral School Modeling of Biomaterials , February 10-16, 2020. Various aspects of TOF modeling, as well as interactions between medicine and mathematics were discussed.
- November 4-7, 2019: Visit of R. Chabiniok & T. Hussain (via telco from Dallas) at IKEM and Czech Technical University and Charles University in Prague while discussing on modeling for large-vessel flow (TOFMOD objectives #3).
- October 14-18, 2019: Visit of R. Chabiniok at UTSW Medical Center Dallas, discussing the TOFMOD projects and official interviews of R. Chabiniok to joint UTSW team in 2020 and work on TOFMOD objectives #1-3 while being (mostly) affiliated in the clinical team.
- June 23-26, 2019: Visit of T. Hussain at Inria Saclay to discuss the ToFMOD projects (TOFMOD objectives #1-3)
- June 10-21, 2019: A project implementing motion tracking tool developed by M. Genet directly at Children's hospital, UTSW Medica Center Dallas (visit of UTSW by R. Chabiniok and K. Skardova, while M. Genet joined by daily teleconferences), TOFMOD objective #2. As one outcome of the work is an abstract accepted to SCMR (world main conference of Cardiovascular Magnetic Resonance imaging): D.A. Castellanos, K. Skardova (Solovska), A. Bhattaru, G. Greil, A. Tandon, J. Dillenbeck, B. Burkhardt, T. Hussain, M. Genet, R. Chabiniok: Left ventricular torsion obtained using equilibrated warping in patients with repaired Tetralogy of Fallot & journal paper is currently in preparation.
- Conference paper supported by TOFMOD K. Skardova (Solovska), M. Rambausek, R. Chabiniok, M. Genet: Mechanical and Imaging Models-based Image Registration, Proc. of VipIMAGE 2019, Volume 34 of Lecture Notes in Computational Vision and Biomechanics, pp. 77-85, Springer, Cham, was presented by M. Genet at VipIMAGE2019 conference in Porto, TOFMOD objective #2.
- Conference paper supported by TOFMOD B. Ruijsink, K. Zugaj, K. Pushparajah, R. Chabiniok: Model-based indices of early-stage cardiovascular failure and its therapeutic management in Fontan patients, Proc. FIMH 2019, was presented at Functional Imaging and Modelling of Heart Conference (May 2019), TOFMOD objective #1.
- May 6-10, 2019: Visit of R. Chabiniok at UTSW Medical Center Dallas, followed by R. Chabiniok and T. Hussain joining Annual meeting of International Society of Magnetic Resonance in Medicine (ISMRM) in Montreal, where presenting TOFMOD objective #1
- January 7-18, 2019: Visit of K. Solovska (Skardova) at Inria Saclay, leading to submitting a conference paper "K. Solovska, et al: Mechanical and Imaging Models-based Image Registration, VipIMAGE 2019 conference (Porto, Portugal)", TOFMOD objective #2.
- Decemeber 17, 2018: R. Chabiniok invited to give a seminar at Children's Heart Center, University Hospital Motol, Prague, Czech Republic (by Prof. J. Janousek), interaction of TOFMOD with Children't Heart Centre in Prague was discussed
- October 5-10, 2018: visit of Animesh (Aashoo) Tandon from UTSW Dallas at Inria Saclay (discussions in the PhD project of M. Gusseva, and new clinical data of teralogy of Fallot patients from UTSW Dallas, and University of Austin)
- September 19, 2018: R. Chabiniok invited to give a whole-institute seminar at Institution for Clinical and Experimental Medicine, IKEM Prague, Czech Republic (invitation by scientific council of IKEM) on Clinical applications of cardiac modelling
- August 1-30, 2018: summer internship of K. Solovska (associated partner institute from Prague) working with M. Genet and R. Chabiniok on model-based motion extraction from CMR images
- June 21, 2018: Presenting ToFMOD at World Congres of Biomechanics, WCB 2018, Dublin, Ireland
- June 22, 2018: TOFMOD MRI & Modeling workshop 2018, Inria Saclay Ile-de-France
- June 20, 2018: Presenting TOFMOD at main world clinical conference on magnetic resonance imaging in medicine ISMRM 2018, Paris, France
- November 1, 2017: launching a PhD of Maria Gusseva jointly supervised between Inria (R. Chabiniok and D. Chapelle) and UTSW Medical Center Dallas (T. Hussain)